A bus full of strangers breaks down in the middle of nowhere. As they rummage through a ghost town looking for a way to call for help, one of them reads from an ancient gothic tome, bringing six of the world's most notorious serial killers back to life. With the killers on the loose, they start to pick off the travelers one at a time using increasingly gruesome methods. In order to get out alive, the surviving travelers will have to find a way to send the killers back to the depths of Hell.