As a young artist with great aspirations, Nate Harris was determined to get rich or die tryin; he was driven to be somebody. In rap's hottest city, Miami, home of South Beach, sunshine and sex appeal, Know Thy Enemy chronicles one man's rise from the streets of the 305 to the top of the billboard charts. Nemesis (Nate) is pressured into becoming a stereotypical gangster rapper in order to get signed and achieve success. Fame quickly follows, but at a price; inundated with drugs, sex, guns and money, his life is at stake and he questions if getting rich and winning the game is worth dying for.