Charlton Heston and Rex Harrison portray two of the Renaissance's most colorful figures in this historical drama based on Irving Stone's best-seller set in the early 16th century. When Pope Julius ll (Rex Harrison) commissions Michelangelo (Charlton Heston) to paint the ceiling of the Sistine Chapel, the artist initially refuses. Virtually forced to do the job by Julius, Michelangelo later destroys his own work and flees to Rome. Eventually resumed, the project becomes a battle of wills fueled by artistic and temperamental differences that form the core of this movie. The Agony and the Ecstasy was nominated for an Oscar for Cinematography, and named one of the best films of 1965 by the National Board of Review.