In Tokyo, a weak, unassertive boy named Sena Kobayakawa enters the high school of his choice, Deimon Private Senior High School. Sena's only remarkable physical abilities are his running speed and agility, which are noted by the school's American football team captain Yoichi Hiruma. Hiruma forces Sena to join the Deimon Devil Bats football team as its running back. To protect his identity from other teams who want to recruit him, Sena is forced to publicly assume the role of the team secretary and enter the field under the pseudonym of "Eyeshield 21" wearing a helmet with an eyeshield to hide his features.
| Title | Time | |
|---|---|---|
| 1 | The Man With The Lightspeed Legs! | 2005-04-06 |
| 2 | Let's Play American Football! | 2005-04-13 |
| 3 | Blaze A Path Down The Field! | 2005-04-20 |
| 4 | What I Hold In My Hands! | 2005-04-27 |
| 5 | Half-Second Body Guards! | 2005-05-04 |
| 6 | The Pierce Of The Spear Tackle! | 2005-05-11 |
| 7 | Fighting to Win! | 2005-05-18 |
| 8 | Never Quit! | 2005-05-25 |
| 9 | The Catching Master! | 2005-06-01 |
| 10 | A Hero's Qualifications! | 2005-06-08 |
| 11 | Oath Under The Setting Sun! | 2005-06-15 |
| 12 | Max Catch! | 2005-06-22 |
| 13 | The Terror Of The Chameleon! | 2005-06-29 |
| 14 | The Scorching Hell Tower! | 2005-07-06 |
| 15 | Find Eyeshield! | 2005-07-13 |
| 16 | Farewell, Kurita?! | 2005-07-20 |
| 17 | The Kid And Iron Horse! | 2005-07-27 |
| 18 | A Slacker's Pride! | 2005-08-10 |
| 19 | The Lower-Class Laughs At Its Challengers! | 2005-08-27 |
| 20 | The Sphinx's Secret Weapon! | 2005-08-24 |
| 21 | Fly, Devil Bat! | 2005-08-31 |
| 22 | A Mysterious Girl Appears! | 2005-09-07 |
| 23 | The Weightless Man | 2005-09-07 |
| 24 | Blitz! Japan vs. USA! | 2005-09-14 |
| 25 | The Caged Black Panther! | 2005-09-21 |
| 26 | A Real Beast | 2005-09-28 |
| 27 | Take Back Cerberus! | 2005-10-05 |
| 28 | American Football Downtown! | 2005-10-12 |
| 29 | Ultimate Combo! The Devil Gunmen! | 2005-10-19 |
| 30 | At The Gates Of Hell! | 2005-10-26 |
| 31 | Minds Made Up! | 2005-11-02 |
| 32 | Quitters? | 2005-11-09 |
| 33 | Oh! My Sister! | 2005-11-16 |
| 34 | Signs Of A Ghost! | 2005-11-23 |
| 35 | A Solitary Death March! | 2005-11-30 |
| 36 | The Final Trial! | 2005-12-07 |
| 37 | The Distant Peak | 2005-12-14 |
| 38 | The New Starting Lineup | 2006-01-11 |
| 39 | The Road To The Christmas Bowl! | 2006-01-11 |
| 40 | The Night Before The Game! | 2006-01-11 |
| 41 | The Ace's Missing?! | 2006-01-18 |
| 42 | The Devil Bat Ghost! | 2006-01-25 |
| 43 | The Legendary 60-Yard Magnum! | 2006-02-01 |
| 44 | A ha ha! My Debut! | 2006-02-08 |
| 45 | The Ghost Is Sealed?! | 2006-02-15 |
| 46 | The Ghost vs. The Spear! | 2006-02-22 |
| 47 | Hot! Guts! Fire! | 2006-03-01 |
| 48 | A Battle Of Effort, Fortitude, And Will! | 2006-03-08 |
| 49 | The Refined Spirit Of A Lineman! | 2006-03-15 |
| 50 | The Courage To Stand Firm. | 2006-03-22 |
| 51 | Danger! The Lethal Cameleon | 2006-03-29 |
| 52 | Clash! Cameleon vs Poseidon | 2006-04-05 |
| 53 | Fear Of The Poisonous Scorpion! | 2006-04-12 |
| 54 | The Control Tower Which Disappeared | 2006-04-19 |
| 55 | Wall Of The Physique Difference | 2006-04-26 |
| 56 | Our Small Contract! | 2006-05-03 |
| 57 | The Man Who Knows 21 | 2006-05-10 |
| 58 | Devil vs Sea God | 2006-05-17 |
| 59 | Back Ace Man | 2006-05-24 |
| 60 | Promise On The Field! | 2006-05-31 |
| 61 | Determination To Win! | 2006-06-07 |
| 62 | Terror! Moby Dick Anchor | 2006-06-14 |
| 63 | Offense And Defence 30 cm!! | 2006-06-21 |
| 64 | The Man Possessing Speed Of Light Appears!? | 2006-06-28 |
| 65 | Deimon High School Sports Meet!! | 2006-07-05 |
| 66 | Sprinter Sena!? | 2006-07-12 |
| 67 | Promise Of The Three | 2006-07-19 |
| 68 | Fastest Proof | 2006-07-26 |
| 69 | Field Of Desperation | 2006-08-09 |
| 70 | Musashi Is Here | 2006-08-16 |
| 71 | The Devil's Counterattack | 2006-08-23 |
| 72 | Pride Of Speed Of Light | 2006-08-30 |
| 73 | Fated Kick | 2006-09-06 |
| 74 | A Rival's Promise | 2006-09-06 |
| 75 | Spider's Threat | 2006-09-13 |
| 76 | Come Back! Musashi! | 2006-09-20 |
| 77 | The Real | 2006-09-27 |
| 78 | The One That Waits Previously | 2006-10-04 |
| 79 | Kobayakawa Sena | 2006-10-11 |
| 80 | The Strongest Kick Team | 2006-10-18 |
| 81 | The Truth Of Red Pupil | 2006-11-01 |
| 82 | Run! Musashi! | 2006-11-08 |
| 83 | Time That Began To Move | 2006-11-15 |
| 84 | The Devil In The Storm | 2006-11-22 |
| 85 | The Man Who Is Loved By God | 2006-11-29 |
| 86 | Time Up Of The Light And Shadow | 2006-12-06 |
| 87 | The Strongest Soldiers In Tokyo!! | 2006-12-13 |
| 88 | Deimon's Halftime Show | 2006-12-20 |
| 89 | Opening! Cream Puff Cup!! | 2007-01-04 |
| 90 | Brand New Trial | 2007-01-10 |
| 91 | Fighting Spirit! Death Climb | 2007-01-17 |
| 92 | 3 Brothers Of Texas Ranch | 2007-01-24 |
| 93 | Yell Of Friendship | 2007-01-31 |
| 94 | Secret Weapon In Silverly White | 2007-02-07 |
| 95 | Break Down The Wall Of Blizzard | 2007-02-14 |
| 96 | Now! To The Kantou Meet! | 2007-02-21 |
| 97 | Farewell, Onihei | 2007-02-28 |
| 98 | Cameleon's Counterattack! | 2007-03-07 |
| 99 | Deimon High School Festival!! | 2007-03-21 |
| 100 | The Invisible Lock | 2007-03-28 |
| 101 | Strongest Evil | 2007-04-11 |
| 102 | Overcome Your Fears | 2007-04-18 |
| 103 | The Iron Wall Double Stopper | 2007-04-25 |
| 104 | One Line Lacking | 2007-05-02 |
| 105 | The Final Death Game | 2007-05-09 |
| 106 | Fieresome God, Kongou Agon | 2007-05-16 |
| 107 | The Enemy Is Shinryuuji | 2007-05-30 |
| 108 | Detective Sena!? | 2007-06-06 |
| 109 | Talent of Catching | 2007-06-13 |
| 110 | Barrier Of Talent | 2007-06-20 |
| 111 | Go Forth, Devil Bats! | 2007-06-27 |
| 112 | Devil vs God! | 2007-07-04 |
| 113 | The Twelfth Athlete | 2007-07-11 |
| 114 | Mediocre Power | 2007-07-18 |
| 115 | Number One Is Trapped | 2007-07-25 |
| 116 | The Will Of A Warrior | 2007-08-08 |
| 117 | Time Out Zero | 2007-08-22 |
| 118 | Huddle Without Answers | 2007-08-29 |
| 119 | To The Limits Of The Death Battle | 2007-09-05 |
| 120 | Super Dreadnaught! Dinosaurs!! | 2007-09-12 |
| 121 | Battlefied Of The Wolves | 2007-09-19 |
| 122 | Rodeo Drive Stampede | 2007-09-26 |
| 123 | The Knight With No Weakness | 2007-10-03 |
| 124 | Ultimate Spear!! | 2007-10-17 |
| 125 | White Knights High School Festival! | 2007-10-24 |
| 126 | Promise To Become An Ace | 2007-10-31 |
| 127 | Just For Victory | 2007-11-07 |
| 128 | Devil vs. Man With The Speed Of Light | 2007-11-14 |
| 129 | A Challenge To The King | 2007-11-21 |
| 130 | Fanfare Start | 2007-11-28 |
| 131 | Prison Chain Of Wrath | 2007-12-05 |
| 132 | The Knight Who Commands The Sky | 2007-12-12 |
| 133 | Ballista Of The Kingdom | 2007-12-19 |
| 134 | Invincible Barrier | 2008-01-04 |
| 135 | Peerless Superman | 2008-01-09 |
| 136 | 21 Defeated | 2008-01-16 |
| 137 | Half Time Of Fate | 2008-01-23 |
| 138 | Ground Battle After The Rain | 2008-01-30 |
| 139 | The 9999th Catch | 2008-02-06 |
| 140 | Two Aces | 2008-02-13 |
| 141 | Devil Stun Gun Initiated | 2008-02-20 |
| 142 | Devil's Wings | 2008-02-27 |
| 143 | A Deep Attachment | 2008-03-05 |
| 144 | The Last Moment | 2008-03-12 |
| 145 | Everybody, Let's Play American Football! | 2008-03-19 |
