Professor Utonium and his son Ken are studying the strange Chemical X. When a mochi cake falls into the formula, it changes into Chemical Z. Ken fires a ray of Chemical Z at a glacier in Tokyo Bay, however that causes strange lights to scatter, some of them aim at three normal girls, Momoko, Miyako, and Kaoru. This gives them the power to transform into superheroes, the Powerpuff Girls Z!
| Title | Time | |
|---|---|---|
| 1 | Arrival of the Girls! / Birth of the Girls! | 2006-07-01 |
| 2 | Relaxing Bubbles Part 1 / Relaxing Bubbles Part 2 | 2006-07-08 |
| 3 | Girls United! Part 1 / Girls United! Part 2 | 2006-07-15 |
| 4 | The Girls' Family Bond Part 1 / The Girls' Family Bond Part | 2006-07-22 |
| 5 | Mojo's Revenge! / The Observatory Tower Crash! | 2006-07-29 |
| 6 | Fuzzy Lumpkins! / Himeko the Princess! | 2006-08-05 |
| 7 | Make It Come True! Momoko's Love / Heinous Trio? The Amoeba | 2006-08-12 |
| 8 | The Attractive Lady! Sedusa Part 1 / The Attractive Lady! Se | 2006-08-19 |
| 9 | Coach Kaoru's Crash-Course Soccer! / Fuzzy in Love! | 2006-08-26 |
| 10 | Charisma Beautician Monster! Part 1 / Charisma Beautician Mo | 2006-09-02 |
| 11 | Princess Even in Space! / Chase the Cake Thief! | 2006-09-09 |
| 12 | The Soap Bubbles of First Love Part 1 / The Soap Bubbles of | 2006-09-16 |
| 13 | Apprenticed by Mojo! The Amoeba Boys / The Camera Monster's | 2006-09-23 |
| 14 | The Gangreen Gang! Part 1 / The Gangreen Gang! Part 2 | 2006-09-30 |
| 15 | The Targeted Fashion Show! / The Man! The Ramen Monster! | 2006-10-07 |
| 16 | Sorrow! Princess' Secret Part 1 / Sorrow! Princess' Secret P | 2006-10-14 |
| 17 | Don't Let the Shutter Chance Escape! / Brotherly Love! The E | 2006-10-21 |
| 18 | Monster Tag Battle! Part 1 / Monster Tag Battle! Part 2 | 2006-10-28 |
| 19 | A Sorrowful Piano Lesson! / The Strongest! Keane-sensei | 2006-11-04 |
| 20 | The Rowdyruff Boys Part 1 / The Rowdyruff Boys Part 2 | 2006-11-11 |
| 21 | The Waddling Rubber Duck Monster! / The Disliked Vegetables' | 2006-11-18 |
| 22 | The Most Evil of Them All, "Him"! Part 1 / The Most Evil of | 2006-11-25 |
| 23 | A Comedy of Terrors / Beetle Battle | 2006-12-02 |
| 24 | A Ken in Need is a Friend Indeed | 2006-12-09 |
| 25 | The Write and the Wrong Way / Flower Power | 2006-12-16 |
| 26 | All Ken Wants for Christmas | 2006-12-23 |
| 27 | Grabbing and Eating! Sushi Monster! / Peach and Sapphire! | 2007-01-06 |
| 28 | Ladies' Tag Battle! Part 1 / Ladies' Tag Battle! Part 2 | 2007-01-13 |
| 29 | Let's Go to the Dentist! / Saturday Powerpuff Fever | 2007-01-20 |
| 30 | The Girls and "Him"! Part 1 / The Girls and "Him"! Part 2 | 2007-01-27 |
| 31 | Funta's Rolling Spirit / Sedusa's Love Tactics!? | 2007-02-03 |
| 32 | Head Over Heels in Love with Momoko! Part 1 / Head Over Heel | 2007-02-10 |
| 33 | Runaway Momoko and Neapolitan! / Keane's Sympathy, Mojo's Af | 2007-02-17 |
| 34 | The House Where the Ghost Lives!? Part 1 / The House Where t | 2007-02-24 |
| 35 | We're Not Weeds! / Monster, The Laws of Compassion! | 2007-03-03 |
| 36 | Powerpuff Girls Z, Break Up!? Part 1 / Powerpuff Girls Z, Br | 2007-03-10 |
| 37 | Super Tough Girls / Powerpuff Boys Z | 2007-03-17 |
| 38 | Enter the Entourage | 2007-03-24 |
| 39 | Little Ken's Big Wish / Wild Moon Chase | 2007-03-31 |
| 40 | Babes in TV Land / The Legend of Princess Morbucks | 2007-04-07 |
| 41 | The Mighty Morbucks / Trading Faces | 2007-04-14 |
| 42 | The Rowdyruff Girls | 2007-04-21 |
| 43 | The Professor Gets His Cut / Who is Lucas Clark? | 2007-04-28 |
| 44 | Buttercup's New Moves | 2007-05-05 |
| 45 | Hoppily Ever After / Vamp on Campus | 2007-05-12 |
| 46 | Return of Him | 2007-05-19 |
| 47 | Keane For a Break / Like Giving Candy to a Baby | 2007-05-26 |
| 48 | Bubbles and the Beast | 2007-06-02 |
| 49 | The Happy Thought Blaster / Nurse Curse | 2007-06-09 |
| 50 | Him's Big Plan | 2007-06-16 |
| 51 | Only a Matter of Time | 2007-06-23 |
| 52 | The Final Battle | 2007-06-30 |
